Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …

Ribosomopathies compose a collection of disorders in which genetic abnormalities cause
impaired ribosome biogenesis and function, resulting in specific clinical phenotypes …

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability,
metabolism and ageing,. SIRT7 is a mammalian sirtuin whose biochemical activity …

Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal …

Ribosomal proteins are ubiquitous, abundant, and RNA binding: prime candidates for
recruitment to extraribosomal functions. Indeed, they participate in balancing the synthesis of …

Introduction The importance of the tumor microenvironment in breast cancer has been
increasingly recognized. Critical molecular changes in the tumor stroma accompanying …

To study the multistep process of cervical cancer development, we analyzed 128 frozen
cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia …

Somatic chromosomal deletions in cancer are thought to indicate the location of tumour
suppressor genes, by which a complete loss of gene function occurs through biallelic …