Aims In this exciting era of gene discovery, we review evidence from family, adoption and
twin studies that examine the genetic basis for addiction. With a focus on the classical twin …

With the rapid advances in molecular biology, the near completion of the human genome,
the development of appropriate statistical genetic methods and the availability of the …

β-Thalassemia and sickle cell disease both display a great deal of phenotypic
heterogeneity, despite being generally thought of as simple Mendelian diseases. The …

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide
association study with more than 300,000 SNPs characterized in 547 patients and 928 …

Fig. 1 Pedigrees used in timing experiments. Filled symbols represent affected individuals
and genotypes are unavailable for individua ls represented by symbols with a slash. a …

This well-organized and clearly written text has a unique focus on methods of identifying the
joint effects of genes and environment on disease patterns. It follows the natural sequence of …

Utilising data derived from twins and their families, different approaches can be applied to
study genetic and environmental influences on human dental variation. The different …

Single-nucleotide polymorphisms (SNPs) are rapidly replacing microsatellites as the
markers of choice for genetic linkage studies and many other studies of human pedigrees …

Bone mineral density (BMD), a diagnostic parameter for osteoporosis and a clinical predictor
of fracture, is a polygenic trait with high heritability. To identify genetic variants that influence …

Linear mixed models (LMMs) are among the most commonly used tools for genetic
association studies. However, the standard method for estimating variance components in …