Arsenic exposure and toxicology: a historical perspective

MF Hughes, BD Beck, Y Chen, AS Lewis… - Toxicological …, 2011 - academic.oup.com
The metalloid arsenic is a natural environmental contaminant to which humans are routinely
exposed in food, water, air, and soil. Arsenic has a long history of use as a homicidal agent …

Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach

JS Tsuji, ET Chang, PR Gentry, HJ Clewell… - Critical reviews in …, 2019 - Taylor & Francis
The biologic effects of inorganic arsenic predominantly involve reaction of the trivalent forms
with sulfhydryl groups in critical proteins in target cells, potentially leading to various …

Comparative evaluation of in vivo relative bioavailability and in vitro bioaccessibility of arsenic in leafy vegetables and its implication in human exposure assessment

X Zheng, Z Zhang, J Chen, H Liang, X Chen… - Journal of Hazardous …, 2022 - Elsevier
Arsenic (As) contamination in vegetables is a severe threat to human health. However, the
evaluation of As relative bioavailability (As-RBA) or bioaccessibility in vegetables is still …

[HTML][HTML] Association of low-level arsenic exposure in drinking water with cardiovascular disease: a systematic review and risk assessment

JS Tsuji, V Perez, MR Garry, DD Alexander - Toxicology, 2014 - Elsevier
Abstract The US Environmental Protection Agency (EPA) is developing an integrated
assessment of non-cancer and cancer risk assessment of inorganic arsenic (iAs) …

Comparative toxicity of arsenic metabolites in human bladder cancer EJ-1 cells

H Naranmandura, MW Carew, S Xu, J Lee… - Chemical research in …, 2011 - ACS Publications
The human bladder is one of the primary target organs for arsenic-induced carcinogenicity,
and arsenic metabolites in urine have been suspected to be directly involved in …

Arsenic metabolism and thioarsenicals

K Rehman, H Naranmandura - Metallomics, 2012 - academic.oup.com
Arsenic has received considerable attention in the world, since it can lead to a multitude of
toxic effects and has been recognized as a human carcinogen causing cancers. Here, we …

Coupled techniques for arsenic speciation in food and drinking water: a review

B Sadee, ME Foulkes, SJ Hill - Journal of Analytical Atomic …, 2015 - pubs.rsc.org
Arsenic is ubiquitous in nature appearing in various chemical forms. The toxicity,
environmental mobility and accumulation of As in living organisms depends on the form in …

Cellular arsenic transport pathways in mammals

BA Roggenbeck, M Banerjee, EM Leslie - Journal of Environmental …, 2016 - Elsevier
Natural contamination of drinking water with arsenic results in the exposure of millions of
people world-wide to unacceptable levels of this metalloid. This is a serious global health …

Arsenic and the gastrointestinal tract microbiome

TR McDermott, JF Stolz… - Environmental …, 2020 - Wiley Online Library
Arsenic is a toxin, ranking first on the Agency for Toxic Substances and Disease Registry
and the Environmental Protection Agency Priority List of Hazardous Substances. Chronic …

Inorganic arsenic: A non-genotoxic carcinogen

SM Cohen, A Chowdhury, LL Arnold - Journal of Environmental Sciences, 2016 - Elsevier
Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for
cancer and non-cancer effects involves the metabolic generation of trivalent arsenicals and …