Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …

Mesenchymal stem cells (MSCs) are a type of stromal cells characterized by their properties
of self-renewal and multi-lineage differentiation, which make them prominent in regenerative …

Summary KRAS G12D is the most frequently mutated oncogenic KRAS subtype in solid
tumors and remains undruggable in clinical settings. Here, we developed a high affinity …

Mutations in the RAS–RAF–MEK–ERK pathway are frequent alterations in cancer and
RASopathies, and while RAS oncogene activation alone affects 19% of all patients and …

Kirsten rat sarcoma virus oncogene homolog (KRAS) is the most frequently mutated
oncogene in human cancer. In colorectal cancer (CRC), KRAS mutations are present in …

Mutations in the KRAS gene are among the most common mutations observed in cancer
cells, but they have only recently become an achievable goal for targeted therapies. Two …

Pancreatic cancer (PC), a disease with high heterogeneity and a dense stromal
microenvironment, presents significant challenges and a bleak prognosis. Recent …

KRAS plays a crucial role in regulating cell survival and proliferation and is one of the most
commonly mutated oncogenes in human cancers. The novel KRAS G12D inhibitor …

Lung cancer is the most common cause of cancer-related deaths globally, with the highest
mortality rates among both men and women. Most lung cancers are diagnosed at late …

Pseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation
of mucus in the peritoneal cavity. The only effective treatment is aggressive surgery, aimed …