Thiamine (vitamin B1) is a precursor of the well-known coenzyme of central metabolic
pathways thiamine diphosphate (ThDP). Highly intense glucose oxidation in the brain …

Certain metabolic interventions such as caloric restriction, fasting, exercise, and a ketogenic
diet extend lifespan and/or health span. However, their benefits are limited and their …

Epilepsy is characterized by recurrent seizures due to a perturbed balance between
glutamate and GABA neurotransmission. Our goal is to reveal the molecular mechanisms of …

Background and purpose Based on the fact that traumatic brain injury is associated with
mitochondrial dysfunction we aimed at localization of mitochondrial defect and attempted to …

Simple Summary The molecular mechanisms of Charcot–Marie–Tooth (CMT) disease,
involving impaired vitamin metabolism and/or actions, are considered in light of the potential …

Background The DHTKD1-encoded 2-oxoadipate dehydrogenase (OADH) oxidizes 2-
oxoadipate—a common intermediate of the lysine and tryptophan catabolism. The mostly …

Our study aims at developing knowledge-based strategies minimizing chronic changes in
the brain after severe spinal cord injury (SCI). The SCI-induced long-term metabolic …

Abnormal energy expenditure during seizures and metabolic regulation through post-
translational protein acylation suggest acylation as a therapeutic target in epilepsy. Our goal …

Glutamate dehydrogenase (GDH) is essential for the brain function and highly regulated,
according to its role in metabolism of the major excitatory neurotransmitter glutamate. Here …

Hypoxia is damaging to the fetus, but the developmental impact may vary, with underlying
molecular mechanisms unclear. We demonstrate the dependence of physiological and …