Clopidogrel is a widely-used antiplatelet drug. It is important for the treatment and prevention
of coronary heart disease. Clopidogrel can effectively reduce platelet activity and therefore …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• CYP2C19 polymorphisms may have
clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently …

The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and
CYP2C19 metabolic phenotypes ('predicted'from genotypes and 'measured'with a probe …

What is known and objective Genetic polymorphism is one of the most important factors
responsible for interindividual and interethnic variability in drug response. Studies in major …

Antifungal agents may be associated with significant toxicity or drug interactions leading to
sub‐therapeutic antifungal drug concentrations and poorer clinical outcomes for patients …

More than 30 years of genetic research on the CYP2C19 gene alone has identified
approximately 2,000 reference single nucleotide polymorphisms (rsSNPs) containing 28 …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Introduction: The cytochrome P450 (CYP) enzymes are the major enzymes responsible for
Phase I reactions in the metabolism of several substances, including antidepressant …

Polymorphisms in the cytochrome P (CYP) 450 family may cause adverse drug responses in
individuals. Cytochrome P450 2C19 (CYP2C19) is a member of the CYP family, where the …