Epstein–Barr virus latent genes
MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …
[HTML][HTML] Regulation of Bim in health and disease
The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …
under both physiological and pathophysiological conditions. Tight regulation of its …
Epigenetic lifestyle of Epstein-Barr virus
A Buschle, W Hammerschmidt - Seminars in immunopathology, 2020 - Springer
Epstein-Barr virus (EBV) is a model of herpesvirus latency and epigenetic changes. The
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …
Epstein–Barr virus-associated malignancies: Roles of viral oncoproteins in carcinogenesis
The Epstein–Barr virus (EBV) is the first herpesvirus identified to be associated with human
cancers known to infect the majority of the world population. EBV-associated malignancies …
cancers known to infect the majority of the world population. EBV-associated malignancies …
Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr virus infection
Epstein-Barr virus infection of B lymphocytes elicits diverse host responses via well-adapted
transcriptional control dynamics. Consequently, this host-pathogen interaction provides a …
transcriptional control dynamics. Consequently, this host-pathogen interaction provides a …
EBNA2-EBF1 complexes promote MYC expression and metabolic processes driving S-phase progression of Epstein-Barr virus–infected B cells
Epstein-Barr virus (EBV) is a human tumor virus which preferentially infects resting human B
cells. Upon infection in vitro, EBV activates and immortalizes these cells. The viral latent …
cells. Upon infection in vitro, EBV activates and immortalizes these cells. The viral latent …
Epstein-Barr virus latency: current and future perspectives
B Kempkes, ES Robertson - Current Opinion in Virology, 2015 - Elsevier
Highlights•EBV is an oncogenic gammaherpesvirus that transforms human primary B-
cells.•EBV encoded transcription factors assemble at primed enhancers to activate cell …
cells.•EBV encoded transcription factors assemble at primed enhancers to activate cell …
RNA sequencing analyses of gene expression during Epstein-Barr virus infection of primary B lymphocytes
Epstein-Barr virus (EBV) infection of human primary resting B lymphocytes (RBLs) leads to
the establishment of lymphoblastoid cell lines (LCLs) that can grow indefinitely in vitro. EBV …
the establishment of lymphoblastoid cell lines (LCLs) that can grow indefinitely in vitro. EBV …
Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines
ED SoRelle, J Dai, EN Bonglack, EM Heckenberg… - Elife, 2021 - elifesciences.org
Lymphoblastoid cell lines (LCLs) are generated by transforming primary B cells with Epstein–
Barr virus (EBV) and are used extensively as model systems in viral oncology, immunology …
Barr virus (EBV) and are used extensively as model systems in viral oncology, immunology …
A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid
cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin …
cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin …