Atomic force microscopy (AFM) and its applications to bone-related research

Y Zhou, J Du - Progress in Biophysics and Molecular Biology, 2022 - Elsevier
Bone consists of organic (mostly collagen) and inorganic (mostly bioapatite mineral)
components that are organized into hierarchical structures from nano-to macro-scales that …

Determining spatial variability of elastic properties for biological samples using AFM

SV Kontomaris, A Stylianou, G Chliveros, A Malamou - Micromachines, 2023 - mdpi.com
Measuring the mechanical properties (ie, elasticity in terms of Young's modulus) of
biological samples using Atomic Force Microscopy (AFM) indentation at the nanoscale has …

Revealing Layer‐Specific Ultrastructure and Nanomechanics of Fibrillar Collagen in Human Aorta via Atomic Force Microscopy Testing: Implications on Tissue …

M Asgari, N Latifi, F Giovanniello… - Advanced …, 2022 - Wiley Online Library
Soft biological tissues are natural biomaterials with structures that have evolved to perform
physiological functions, for example, conferring elasticity while preserving the mechanical …

Nanomechanical mapping of hard tissues by atomic force microscopy: An application to cortical bone

M Bontempi, F Salamanna, R Capozza, A Visani… - Materials, 2022 - mdpi.com
Force mapping of biological tissues via atomic force microscopy (AFM) probes the
mechanical properties of samples within a given topography, revealing the interplay …

Mechanical heterogeneity in the bone microenvironment as characterized by atomic force microscopy

X Chen, R Hughes, N Mullin, RJ Hawkins, I Holen… - Biophysical …, 2020 - cell.com
Bones are structurally heterogeneous organs with diverse functions that undergo
mechanical stimuli across multiple length scales. Mechanical characterization of the bone …

Experimental and numerical investigation of selective laser melting–induced defects in Ti–6Al–4V octet truss lattice material: the role of material microstructure and …

A El Elmi, D Melancon, M Asgari, L Liu… - Journal of Materials …, 2020 - cambridge.org
The remarkable progress in additive manufacturing has promoted the design of architected
materials with mechanical properties that go beyond those of conventional solids. Their …

[HTML][HTML] Designing topographically textured microparticles for induction and modulation of osteogenesis in mesenchymal stem cell engineering

MH Amer, M Alvarez-Paino, J McLaren, F Pappalardo… - Biomaterials, 2021 - Elsevier
Mesenchymal stem cells are the focus of intense research in bone development and
regeneration. The potential of microparticles as modulating moieties of osteogenic response …

An efficient two-scale 3D FE model of the bone fibril array: comparison of anisotropic elastic properties with analytical methods and micro-sample testing

E Alizadeh, M Dehestani, P Zysset - Biomechanics and modeling in …, 2020 - Springer
In this study, 3D finite element analyses (FEA) are conducted to quantify the orthotropic
elastic properties and investigate the load transfer mechanism of bone at the sub-lamellar …

Nano-indentation reveals a potential role for gradients of cell wall stiffness in directional movement of the resurrection plant Selaginella lepidophylla

M Asgari, V Brulé, TL Western, D Pasini - Scientific Reports, 2020 - nature.com
As a physical response to water loss during drought, inner Selaginella lepidophylla stems
curl into a spiral shape to prevent photoirradiation damage to their photosynthetic surfaces …

Biomechanical assessment of different fixation methods in mandibular high sagittal oblique osteotomy using a three-dimensional finite element analysis model

C Savoldelli, E Ehrmann, Y Tillier - Scientific Reports, 2021 - nature.com
With modern-day technical advances, high sagittal oblique osteotomy (HSOO) of the
mandible was recently described as an alternative to bilateral sagittal split osteotomy for the …