Evidence is increasing that disturbances in the gut microbiome may play a significant role in
the etiology of obesity and type 2 diabetes. The short chain fatty acid butyrate, a major end …

Human gut microbiota has been increasingly recognized as a pivotal determinant of non-
alcoholic fatty liver disease (NAFLD). Apart from the changes in the composition of gut …

Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota
through fermentation of dietary fiber. SCFAs participate a number of physiological and …

Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Fatty acid regulation of hepatic gene transcription was first reported in the early 1990s.
Several transcription factors have been identified as targets of fatty acid regulation. This …

Liver plays a central role in modulating blood glucose level. Our most recent findings
suggested that supplementation with microbiota metabolite sodium butyrate (NaB) could …

The aim of this study was to investigate how the effects of compound probiotics modulate the
gut microbiota, short-chain fatty acid (SCFA), body composition, serum and liver lipids, and …

Background Exercise promotes numerous phenotypic adaptations in skeletal muscle that
contribute to improved function and metabolic capacity. An emerging body of evidence …

Historically, the focus of type II diabetes mellitus (T2DM) research has been on host
metabolism and hormone action. However, emerging evidence suggests that the gut …

Over the last decade, a subfamily of G protein-coupled receptors that are agonized by
endogenous and dietary free-fatty acids (FFA) has been discovered. These free-fatty acid …