Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant infections. The …

Abstract Background. Carbapenem-resistant Enterobacteriaceae (CRE) are associated with
considerable mortality. As mechanisms of carbapenem resistance are heterogeneous, it is …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Background. Beta-lactam antibiotics are a commonly used treatment for severe sepsis, with
intermittent bolus dosing standard therapy, despite a strong theoretical rationale for …

Several reports have shown marked heterogeneity of antibiotic pharmacokinetics (PK) in
patients admitted to ICUs, which might potentially affect outcomes. Therefore, the …

Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …