BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Statistical analysis of structural data and detailed inspection of individual crystal structures
culled from the Cambridge Structural Database and the Brookhaven Protein Data Bank …

The marine environment has proven to be a very rich source of extremely potent compounds
that have demonstrated significant activities in antitumor, antiinflammatory, analgesia …

This review describes the various manifestations of the pyrimidine system (alkylated,
glycosylated, benzo‐annelated.). These comprise pyrimidine nucleosides as well as …

Containing fully authenticated data on virtually all known natural products, the" Dictionary of
Natural Products", main work, published in 1993 was the end result of over 12 years …

Covering: 2007. Previous review: Nat. Prod. Rep., 2008, 25, 35This review covers the
literature published in 2007 for marine natural products, with 948 citations (627 for the …

The phosphorylation of proteins on serine, threonine, and tyrosine residues by the 518
protein kinases encoded in the human genome constitutes one of the major mechanisms …

The interdisciplinary field of marine chemical ecology is an expanding and dynamic science.
It is no surprise that the breadth of marine organisms studied expanded in concert with …

Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …