Quantifying T lymphocyte turnover
RJ De Boer, AS Perelson - Journal of theoretical biology, 2013 - Elsevier
Peripheral T cell populations are maintained by production of naive T cells in the thymus,
clonal expansion of activated cells, cellular self-renewal (or homeostatic proliferation), and …
clonal expansion of activated cells, cellular self-renewal (or homeostatic proliferation), and …
Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression
K Poropatich, DJ Sullivan Jr - Journal of General Virology, 2011 - microbiologyresearch.org
A small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive
individuals–referred to as long-term non-progressors (LTNPs)–maintain a favourable course …
individuals–referred to as long-term non-progressors (LTNPs)–maintain a favourable course …
Potent cell-intrinsic immune responses in dendritic cells facilitate HIV-1-specific T cell immunity in HIV-1 elite controllers
The majority of HIV-1 elite controllers (EC) restrict HIV-1 replication through highly functional
HIV-1-specific T cell responses, but mechanisms supporting the evolution of effective HIV-1 …
HIV-1-specific T cell responses, but mechanisms supporting the evolution of effective HIV-1 …
CD161+ MAIT Cells Are Severely Reduced in Peripheral Blood and Lymph Nodes of HIV-Infected Individuals Independently of Disease Progression
JM Eberhard, P Hartjen, S Kummer, RE Schmidt… - PloS one, 2014 - journals.plos.org
Mucosal-associated invariant T (MAIT) cells are characterized by the combined expression
of the semi-invariant T cell receptor (TCR) Vα7. 2, the lectin receptor CD161, as well as IL …
of the semi-invariant T cell receptor (TCR) Vα7. 2, the lectin receptor CD161, as well as IL …
Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers
Elite controllers maintain undetectable levels of HIV-1 replication in the absence of
antiretroviral therapy, but the correlates of immune protection in this patient population are ill …
antiretroviral therapy, but the correlates of immune protection in this patient population are ill …
Immune response to HIV
M Perreau, Y Levy, G Pantaleo - Current Opinion in HIV and AIDS, 2013 - journals.lww.com
In the present review, we shall discuss the different components of the HIV-specific immune
response elicited by the infection, the kinetics of these responses during primary infection …
response elicited by the infection, the kinetics of these responses during primary infection …
Thirty Years with HIV Infection—Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and LongTerm Nonprogressors
JC Gaardbo, HJ Hartling, J Gerstoft… - AIDS research and …, 2012 - Wiley Online Library
In the early days of the HIV epidemic, it was observed that a minority of the infected patients
did not progress to AIDS or death and maintained stable CD4+ cell counts. As the technique …
did not progress to AIDS or death and maintained stable CD4+ cell counts. As the technique …
Human immunodeficiency virus infection: from biological observations to mechanistic mathematical modelling
G Bocharov, V Chereshnev, I Gainova… - … Modelling of Natural …, 2012 - cambridge.org
HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic
mechanisms are manifold and mediated through a range of positive and negative feedback …
mechanisms are manifold and mediated through a range of positive and negative feedback …
Plasmatic Levels of IL-18, IP-10, and Activated CD8+ T Cells Are Potential Biomarkers to Identify HIV-1 Elite Controllers With a True Functional Cure Profile
Elite controllers (ECs) are rare individuals able to naturally control HIV-1 replication below
the detection limit of viral load (VL) commercial assays. It is unclear, however, whether ECs …
the detection limit of viral load (VL) commercial assays. It is unclear, however, whether ECs …
HIV controllers with different viral load cutoff levels have distinct virologic and immunologic profiles
Background: The mechanisms behind natural control of HIV replication are still unclear, and
several studies pointed that elite controllers (ECs) are a heterogeneous group. Methods: We …
several studies pointed that elite controllers (ECs) are a heterogeneous group. Methods: We …