Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …

T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …

The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the
endoplasmic reticulum that is essential for establishing a hierarchical immune response …

Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

IFN-γ up-regulates MHC class I expression and antigen processing and presentation on
cells, since IFN-γ can induce multiple gene expressions that are related to MHC class I …

MHC class I molecules bind short peptides and present them to CD8+ T cells. Contrary to
textbook descriptions, the generation of MHC class-I-associated peptides from endogenous …

The recent discovery of fusion of endoplasmic reticulum membrane with nascent
phagosomes suggests that this peripheral compartment in macrophages and dendritic cells …

Conventionally, MHC class I-restricted antigen (Ag) processing requires the action of the
multimolecular peptide-loading complex within the endoplasmic reticulum (ER). Here we …