Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …

A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

G protein-independent, arrestin-dependent signaling is a paradigm that broadens the
signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous …

β-Arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G
protein signaling, to initiate signaling on their own, and to mediate receptor endocytosis …

G protein-coupled receptors (GPCRs) comprise a large and diverse class of signal-
transducing receptors that undergo dynamic and isoform-specific membrane trafficking …

Serotonin receptors are prevalent throughout the nervous system and the periphery, and
remain one of the most lucrative and promising drug discovery targets for disorders ranging …

Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological
functions and drug action; however, robust quantitative approaches are lacking to study …

β-Arrestins function as endocytic adaptors and mediate trafficking of a variety of cell-surface
receptors, including seven-transmembrane receptors (7TMRs). In the case of 7TMRs, β …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …