In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C)
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Polycomb group proteins have a critical role in silencing transcription during development. It
is commonly proposed that Polycomb-dependent changes in genome folding, which …

Three-dimensional (3D) genomics shows immense promise for studying X chromosome
inactivation (XCI) by interrogating changes to the X chromosomes' 3D states. Here, we …

Abstract Background Topologically associating domains (TADs) are important building
blocks of three-dimensional genome architectures. The formation of TADs has been shown …

Microscopy-based spatially resolved omic methods are transforming the life sciences.
However, these methods rely on high numerical aperture objectives and cannot resolve …

Genomic and transcriptomic image data, represented by DNA and RNA fluorescence in situ
hybridization (FISH), respectively, together with proteomic data, particularly that related to …

Uniquely human physical traits, such as an expanded cerebral cortex and changes in limb
morphology that allow us to use tools and walk upright, are in part due to human-specific …

Polycomb group (PcG) proteins modulate higher-order genome folding and play a critical
role in silencing transcription during development. It is commonly proposed that PcG …