Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …

Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a
challenge in the field of spatial biology. We describe spatial molecular imaging, a system …

Ferroptosis is a mode of regulated cell death characterized by iron-dependent accumulation
of lipid peroxidation. It is closely linked to the pathophysiological processes in many …

In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …

The tricarboxylic acid (TCA) cycle is a central hub of cellular metabolism, oxidizing nutrients
to generate reducing equivalents for energy production and critical metabolites for …

Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image …

Aggressive and metastatic cancers show enhanced metabolic plasticity, but the precise
underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

Targeted protein degradation is a promising area in the discovery and development of
innovative therapeutics. Molecular glues mediate proximity-induced protein degradation and …