Reward contains separable psychological components of learning, incentive motivation and
pleasure. Most computational models have focused only on the learning component of …

This paper presents a biopsychological theory of drug addiction, the 'Incentive-Sensitization
Theory'. The theory addresses three fundamental questions. The first is: why do addicts …

Abstract Schultz, Wolfram. Predictive reward signal of dopamine neurons. J. Neurophysiol.
80: 1–27, 1998. The effects of lesions, receptor blocking, electrical self-stimulation, and …

What roles do mesolimbic and neostriatal dopamine systems play in reward? Do they
mediate the hedonic impact of rewarding stimuli? Do they mediate hedonic reward learning …

OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this
overview is to link the neurobiology (brain), the phenomenological experience (mind), and …

A novel mechanism for regulating dopamine activity in subcortical sites and its possible
relevance to schizophrenia is proposed. This hypothesis is based on the regulation of …

This review gives an overview of recent findings and developments in research on brain
mechanisms of reward and reinforcement from studies using the place preference …

Drug addiction can be conceptualized as a disturbance of behavior motivated by drug-
conditioned incentives. This abnormality has been explained by Incentive-Sensitization and …

While it has previously been assumed that mesolimbic dopamine neurons carry a reward
signal, recent data from single-unit, microdialysis and voltammetry studies suggest that …

The relative contributions of glutamate and dopamine within the nucleus accumbens to
cocaine-induced reinstatement of drug-seeking behavior were assessed. When …