Neuro-bone tissue engineering: multiple potential translational strategies between nerve and bone

Z Zhang, Z Hao, C Xian, Y Fang, B Cheng, J Wu, J Xia - Acta Biomaterialia, 2022 - Elsevier
Numerous tissue regeneration paradigms show evident neurological dependence, including
mammalian fingertip, skin, and bone regeneration. The mature skeleton is innervated by an …

Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization

V Fitzpatrick, Z Martín-Moldes, A Deck… - Biomaterials, 2021 - Elsevier
Our goal was to generate functionalized 3D-printed scaffolds for bone regeneration using
silk-hydroxyapatite bone cements and osteoinductive, proangiogenic and neurotrophic …

Tissue engineered bone mimetics to study bone disorders ex vivo: role of bioinspired materials

YV Shih, S Varghese - Biomaterials, 2019 - Elsevier
Recent advances in materials development and tissue engineering has resulted in a
substantial number of bioinspired materials that recapitulate cardinal features of bone …

3D printing of tree-like scaffolds for innervated bone regeneration

M Zhang, C Qin, Y Wang, X Hu, J Ma, H Zhuang… - Additive …, 2022 - Elsevier
The diversity of phyllotaxis, such as different blade intervals and divergence angles, is the
optimal design for matter exchange and information transfer between plants and external …

Micropathological chip modeling the neurovascular unit response to inflammatory bone condition

E Neto, AC Monteiro, C Leite Pereira… - Advanced …, 2022 - Wiley Online Library
Organ‐on‐a‐chip in vitro platforms accurately mimic complex microenvironments offering
the ability to recapitulate and dissect mechanisms of physiological and pathological settings …

Human dental pulp stem cells exhibit enhanced properties in comparison to human bone marrow stem cells on neurites outgrowth

P Pagella, S Miran, E Neto, I Martin, M Lamghari… - FASEB Journal, 2020 - zora.uzh.ch
Mesenchymal stem cells (MSCs) have the capacity to self‐renew and differentiate into
specific cell types and are, therefore, key players during tissue repair and regeneration. The …

An Elastin‐Derived Composite Matrix for Enhanced Vascularized and Innervated Bone Tissue Reconstruction: From Material Development to Preclinical Evaluation

N Mahmoudi, M Roque… - Advanced …, 2024 - Wiley Online Library
Despite progress in bone tissue engineering, reconstruction of large bone defects remains
an important clinical challenge. Here, a biomaterial designed to recruit bone cells …

The role of nervous system in adaptive response of bone to mechanical loading

Y Qiao, Y Wang, Y Zhou, F Jiang… - Journal of Cellular …, 2019 - Wiley Online Library
Bone tissue is remodeled through the catabolic function of the osteoclasts and the anabolic
function of the osteoblasts. The process of bone homeostasis and metabolism has been …

Peripheral nerves in the tibial subchondral bone: The role of pain and homeostasis in osteoarthritis

Q Sun, G Li, D Liu, W Xie, W Xiao, Y Li… - Bone & Joint …, 2022 - boneandjoint.org.uk
Osteoarthritis (OA) is a highly prevalent degenerative joint disorder characterized by joint
pain and physical disability. Aberrant subchondral bone induces pathological changes and …

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

LA Damiati, M El Soury - Frontiers in Medicine, 2024 - frontiersin.org
Neuro bone tissue engineering is a multidisciplinary field that combines both principles of
neurobiology and bone tissue engineering to develop innovative strategies for repairing and …