Continuous peripheral nerve blocks: an update of the published evidence and comparison with novel, alternative analgesic modalities
BM Ilfeld - Anesthesia & Analgesia, 2017 - journals.lww.com
PaiN Me procedures. Noteworthy exceptions include case reports/series using CPNB to
treat chronic pain such as cancerrelated pain, 3–8 complex regional pain syndrome, 9–12 …
treat chronic pain such as cancerrelated pain, 3–8 complex regional pain syndrome, 9–12 …
Clinical effectiveness of liposomal bupivacaine administered by infiltration or peripheral nerve block to treat postoperative pain: a narrative review
The authors provide a comprehensive summary of all randomized, controlled trials (n= 76)
involving the clinical administration of liposomal bupivacaine (Exparel; Pacira …
involving the clinical administration of liposomal bupivacaine (Exparel; Pacira …
Aromatized liposomes for sustained drug delivery
Insufficient drug loading and leakage of payload remain major challenges in designing
liposome-based drug delivery systems. These phenomena can limit duration of effect and …
liposome-based drug delivery systems. These phenomena can limit duration of effect and …
Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel
Site-1 sodium channel blockers (S1SCBs) act as potent local anaesthetics, but they can
cause severe systemic toxicity. Delivery systems can be used to reduce the toxicity, but the …
cause severe systemic toxicity. Delivery systems can be used to reduce the toxicity, but the …
Are caudal blocks for pain control safe in children? An analysis of 18,650 caudal blocks from the Pediatric Regional Anesthesia Network (PRAN) database
BACKGROUND: The caudal block is the most commonly performed regional anesthesia
technique in pediatric patients undergoing surgical procedures, but safety concerns raised …
technique in pediatric patients undergoing surgical procedures, but safety concerns raised …
[HTML][HTML] Drug delivery systems for prolonged duration local anesthesia
Numerous drug delivery systems have been applied to the problem of providing prolonged
duration local anesthesia (PDLA). Here we review the rationale for PDLA, the desirable …
duration local anesthesia (PDLA). Here we review the rationale for PDLA, the desirable …
Recent advances in polymer-based drug delivery systems for local anesthetics
B Wang, S Wang, Q Zhang, Y Deng, X Li, L Peng… - Acta biomaterialia, 2019 - Elsevier
Local anesthetics, which cause temporary loss of pain by inhibiting the transmission of nerve
impulses, have been widely used in clinical practice. However, neurotoxicity and short half …
impulses, have been widely used in clinical practice. However, neurotoxicity and short half …
[HTML][HTML] Local anaesthetic-induced myotoxicity in regional anaesthesia: a systematic review and empirical analysis
N Hussain, CJL McCartney, JM Neal, J Chippor… - British Journal of …, 2018 - Elsevier
Recent reports of local-anaesthetic (LA)-induced myotoxicity after peripheral nerve blocks
have increased the interest in this less commonly known complication. Basic science …
have increased the interest in this less commonly known complication. Basic science …
Multivesicular liposomal bupivacaine at the sciatic nerve
JB McAlvin, RF Padera, SA Shankarappa, G Reznor… - Biomaterials, 2014 - Elsevier
Clinical translation of sustained release formulations for local anesthetics has been limited
by adverse tissue reaction. Exparel™(DepoFoam bupivacaine) is a new liposomal local …
by adverse tissue reaction. Exparel™(DepoFoam bupivacaine) is a new liposomal local …
Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity
There is clinical and scientific interest in developing local anesthetics with prolonged
durations of effect from single injections. The need for such is highlighted by the current …
durations of effect from single injections. The need for such is highlighted by the current …