Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

While various clinical applications especially in oncology are now in progress such as
diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural …

Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding …

A large number of chemicals and several physical agents, such as UV light and γ-radiation,
have been associated with the etiology of human cancer. Generation of DNA damage (also …

The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and
overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of …

Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

The extracellular matrix (ECM) is an important component of the tumor microenvironment
(TME), having several important roles related to the hallmarks of cancer. In cancer, multiple …

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have
described the beneficial effects of dietary kaempferol in reducing the risk of chronic …

Extensive research within the last several decades has revealed that the major risk factors
for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental …

Many chemotherapeutic drugs have been used for the treatment of cancer, for instance,
doxorubicin, irinotecan, 5-fluorouracil, cisplatin, and paclitaxel. However, the effectiveness of …