[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery

S Fu, Y Wang, X Xia, JC Zheng - NanoImpact, 2020 - Elsevier
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have
been exploited as a promising natural delivery platform due to their low toxicity, excellent …

Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect

V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment

Z Wei, Z Chen, Y Zhao, F Fan, W Xiong, S Song, Y Yin… - Biomaterials, 2021 - Elsevier
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) with anti-apoptotic and
anti-inflammatory properties have been intensively studied. However, rapid clearance by the …

Comparing the therapeutic potential of stem cells and their secretory products in regenerative medicine

JB Foo, QH Looi, PP Chong, NH Hassan… - Stem cells …, 2021 - Wiley Online Library
Cell therapy involves the transplantation of human cells to replace or repair the damaged
tissues and modulate the mechanisms underlying disease initiation and progression in the …

[HTML][HTML] The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction

YY Xiong, ZT Gong, RJ Tang, YJ Yang - Theranostics, 2021 - ncbi.nlm.nih.gov
Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world,
and the inflammatory response plays a pivotal role in the progress of myocardial necrosis …

[HTML][HTML] Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

TT Tang, B Wang, LL Lv, BC Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Dysregulated inflammation is a complicated pathological process involved in various
diseases, and the treatment of inflammation-linked disorders currently represents an …

Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy

SH Khatami, N Karami, M Taheri-Anganeh… - Molecular …, 2023 - Springer
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …