[HTML][HTML] Exosome engineering: Current progress in cargo loading and targeted delivery
Exosomes, a class of small bilayer vesicles derived from virtually all eukaryotic cells, have
been exploited as a promising natural delivery platform due to their low toxicity, excellent …
been exploited as a promising natural delivery platform due to their low toxicity, excellent …
Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases
S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …
Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy
S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …
Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect
V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …
macromolecules deliver their payload selectively to solid tumors. An important driver of …
Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment
Z Wei, Z Chen, Y Zhao, F Fan, W Xiong, S Song, Y Yin… - Biomaterials, 2021 - Elsevier
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) with anti-apoptotic and
anti-inflammatory properties have been intensively studied. However, rapid clearance by the …
anti-inflammatory properties have been intensively studied. However, rapid clearance by the …
Comparing the therapeutic potential of stem cells and their secretory products in regenerative medicine
Cell therapy involves the transplantation of human cells to replace or repair the damaged
tissues and modulate the mechanisms underlying disease initiation and progression in the …
tissues and modulate the mechanisms underlying disease initiation and progression in the …
[HTML][HTML] The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction
YY Xiong, ZT Gong, RJ Tang, YJ Yang - Theranostics, 2021 - ncbi.nlm.nih.gov
Acute myocardial infarction (AMI) is one of the leading causes of mortality around the world,
and the inflammatory response plays a pivotal role in the progress of myocardial necrosis …
and the inflammatory response plays a pivotal role in the progress of myocardial necrosis …
[HTML][HTML] Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy
TT Tang, B Wang, LL Lv, BC Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Dysregulated inflammation is a complicated pathological process involved in various
diseases, and the treatment of inflammation-linked disorders currently represents an …
diseases, and the treatment of inflammation-linked disorders currently represents an …
Exosomes: promising delivery tools for overcoming blood-brain barrier and glioblastoma therapy
Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …
on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis …