Spike timing dependent plasticity: a consequence of more fundamental learning rules
Spike timing dependent plasticity (STDP) is a phenomenon in which the precise timing of
spikes affects the sign and magnitude of changes in synaptic strength. STDP is often …
spikes affects the sign and magnitude of changes in synaptic strength. STDP is often …
AKAP signaling complexes in regulation of excitatory synaptic plasticity
JL Sanderson, ML Dell'Acqua - The Neuroscientist, 2011 - journals.sagepub.com
Plasticity at excitatory glutamatergic synapses in the central nervous system is believed to
be critical for neuronal circuits to process and encode information, allowing animals to …
be critical for neuronal circuits to process and encode information, allowing animals to …
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …
powerful control over neural circuit dynamics that give rise to diverse neural function and …
More than a marker: potential pathogenic functions of MAP2
RA DeGiosio, MJ Grubisha, ML MacDonald… - Frontiers in molecular …, 2022 - frontiersin.org
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation
JC Kuo, X Han, CT Hsiao, JR Yates III… - Nature cell …, 2011 - nature.com
Focal adhesions undergo myosin-II-mediated maturation wherein they grow and change
composition to modulate integrin signalling for cell migration, growth and differentiation. To …
composition to modulate integrin signalling for cell migration, growth and differentiation. To …
Rho GTPase complementation underlies BDNF-dependent homo-and heterosynaptic plasticity
NG Hedrick, SC Harward, CE Hall, H Murakoshi… - Nature, 2016 - nature.com
Abstract The Rho GTPase proteins Rac1, RhoA and Cdc42 have a central role in regulating
the actin cytoskeleton in dendritic spines, thereby exerting control over the structural and …
the actin cytoskeleton in dendritic spines, thereby exerting control over the structural and …
Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP
JN Bourne, KM Harris - Hippocampus, 2011 - Wiley Online Library
Enlargement of dendritic spines and synapses correlates with enhanced synaptic strength
during long‐term potentiation (LTP), especially in immature hippocampal neurons. Less …
during long‐term potentiation (LTP), especially in immature hippocampal neurons. Less …
Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover
Memory formation is believed to result from changes in synapse strength and structure.
While memories may persist for the lifetime of an organism, the proteins and lipids that make …
While memories may persist for the lifetime of an organism, the proteins and lipids that make …
LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity
Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs).
We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs …
We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs …
Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number
Members of the neuroligin family of cell-adhesion proteins are found at excitatory and
inhibitory synapses and are mutated in some familial forms of autism spectrum disorders …
inhibitory synapses and are mutated in some familial forms of autism spectrum disorders …