Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …

Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Control of cancer, neuropathic, and postoperative pain is frequently inadequate or
compromised by debilitating side effects. Inhibition or removal of certain nociceptive …

To investigate whether activation of mitogen-activated protein kinase (MAPK) in damaged
and/or undamaged primary afferents participates in neuropathic pain after partial nerve …

Recent findings indicate that nociceptive nerves are not “free”, but similar to touch and
pressure sensitive nerves, terminate in an end-organ in mice. This sensory structure consists …

Myocardial ischaemia causes the release of metabolites such as bradykinin, which
stimulates cardiac sensory receptors to evoke a sympathoexcitatory reflex. However, the …

Spinal cord stimulation (SCS) is a widely used clinical technique to treat ischemic pain in
peripheral, cardiac and cerebral vascular diseases. The use of this treatment advanced …