As the details of the chemical transformations in metabolism have become increasingly
clear, and the enzymes catalysing many of the reactions have been characterized, it is …

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly
developing field. Such erythrocytes can act as carriers that prolong the drug's action due to …

Erythrocytes are potential biocompatible vectors for different bioactive substances, including
drugs. These can be used successfully as biological carriers of drugs, enzymes and …

This review focuses on the role of human red blood cells (RBCs) as drug carriers. First, a
general introduction about RBC physiology is provided, followed by the presentation of …

Pharmacokinetics, biodistribution, and biological activity are key parameters that determine
the success or failure of therapeutics. Many developments intended to improve their in vivo …

Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by defects in the
phenylalanine hydroxylase gene. Preclinical and clinical investigations suggest that …

Biological drugs are among the most exciting drugs of the future, offering better treatment
options for patients than ever before but they need an appropriate delivery vehicle. Carrier …

Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They
exert their effects through binding with a high affinity and specificity to disease-causing …

Human and murine blood cells treated with ZnCl 2 and bis (sulfosuccinimidyl) suberate (BS
3)(a cross linking agent) undergo band 3 clustering and binding of hemoglobin to red blood …

Extracellular vesicles (EVs) are promising natural nanocarriers for the delivery of therapeutic
agents. As with any other kind of cell, red blood cells (RBCs) produce a limited number of …