Computer-aided drug discovery has been around for decades, although the past few years
have seen a tectonic shift towards embracing computational technologies in both academia …

Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

During the chlor-alkali process, in operation since the nineteenth century, electrolysis of
sodium chloride solutions generates chlorine and sodium hydroxide that are both important …

Conspectus Transition-metal catalyzed cross-coupling reactions are fundamental reactions
in organic chemistry, facilitating strategic bond formations for accessing natural products …

Cross-coupling platforms are traditionally built around a sequence of closed-shell steps,
such as oxidative addition, transmetalation, and reductive elimination. Herein, we describe a …

An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling of
aryl aziridines with alkenyl bromides has been developed, affording enantioenriched β-aryl …

The Kolbe reaction forms carbon-carbon bonds through electrochemical decarboxylative
coupling. Despite more than a century of study, the reaction has seen limited applications …

Disproportionation and comproportionation reactions have become increasingly important
electron transfer events in organometallic chemistry and catalysis. The renewed interest in …

Herein, a facile and general electroreductive deuteration of unactivated alkyl halides (X= Cl,
Br, I) or pseudo-halides (X= OMs) using D2O as the economical deuterium source was …

While the oxidative addition of Ni (I) to aryl iodides has been commonly proposed in catalytic
methods, an in-depth mechanistic understanding of this fundamental process is still lacking …