While originally characterized as a collection of related syndromes, cystic fibrosis (CF) is
now recognized as a single disease whose diverse symptoms stem from the wide tissue …

This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …

Principles of Biostatistics, Third Edition is a concepts-based introduction to statistical
procedures that prepares public health, medical, and life sciences students to conduct and …

Background Respiratory disease in patients with cystic fibrosis is characterized by airway
obstruction caused by the accumulation of thick, purulent secretions, which results in …

The mechanisms underlying the initiation of lung disease and early respiratory morbidity in
cystic fibrosis (CF) are poorly understood. By identifying infants with CF through a statewide …

Cystic fibrosis is the most common potentially lethal autosomal recessive disease of
Caucasians, affecting 1 in 2500 newborns. Since the recent identification of the gene that is …

Despite an increased understanding of the cellular and molecular biology of the CFTR Cl−
channel, it is not known how defective Cl− transport across airway epithelia causes chronic …

Individuals with cystic fibrosis have abbreviated life spans primarily due to chronic airway
infection. A limited number of types of organisms are responsible for these infections, with …

Cystic fibrosis is the most common life-shortening autosomal recessive disorder in the white
population, affecting approximately 30,000 persons in the United States. 1 It is caused by …

With the discovery of the CFTR gene in 1989, the search for therapies to improve the basic
defects of cystic fibrosis (CF) commenced. Pharmacological manipulation provides the …