β-Caryophyllene: a sesquiterpene with countless biological properties

F Francomano, A Caruso, A Barbarossa, A Fazio… - Applied sciences, 2019 - mdpi.com
β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid
agonist of type 2 receptors (CB2-R). It isn't psychogenic due to the absence of an affinity to …

Insight into polyphenol and gut microbiota crosstalk: are their metabolites the key to understand protective effects against metabolic disorders?

M Koudoufio, Y Desjardins, F Feldman, S Spahis… - Antioxidants, 2020 - mdpi.com
Lifestyle factors, especially diet and nutrition, are currently regarded as essential avenues to
decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic …

Obesity and thyroid cancer risk: an update

F Franchini, G Palatucci, A Colao, P Ungaro… - International journal of …, 2022 - mdpi.com
Thyroid cancer (TC) is the most common endocrine malignancy worldwide and its incidence
has increased dramatically in recent years. In parallel, the prevalence of overweight and …

Protective mechanisms of quercetin against myocardial ischemia reperfusion injury

YM Zhang, ZY Zhang, RX Wang - Frontiers in Physiology, 2020 - frontiersin.org
Quercetin has attracted more attention in recent years due to its protective role against
ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the …

Rutin is a low micromolar inhibitor of SARS-CoV-2 main protease 3CLpro: Implications for drug design of quercetin analogs

B Rizzuti, F Grande, F Conforti, A Jimenez-Alesanco… - Biomedicines, 2021 - mdpi.com
The pandemic, due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
stimulated the search for antivirals to tackle COVID-19 infection. Molecules with known …

[HTML][HTML] Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

FT Borsoi, IA Neri-Numa, WQ de Oliveira… - Food Chemistry …, 2023 - Elsevier
Abstract Chronic Non-Communicable Diseases (NCDs) have been considered a global
health problem, characterized as diseases of multiple factors, which are developed …

Plant extracts in prevention of obesity

HN Wang, JZ Xiang, Z Qi, M Du - Critical reviews in food science …, 2022 - Taylor & Francis
Obesity has become a worldwide issue and is accompanied by serious complications.
Western high energy diet has been identified to be a major factor contributing to the current …

Pomegranate: Nutraceutical with promising benefits on human health

A Caruso, A Barbarossa, A Tassone, J Ceramella… - Applied sciences, 2020 - mdpi.com
Pomegranate is an old plant made up by flowers, roots, fruits and leaves, native to Central
Asia and principally cultivated in the Mediterranean and California (although now …

Discovery of a novel 1, 3, 4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental …

S Gastaldi, C Rocca, E Gianquinto, MC Granieri… - European Journal of …, 2023 - Elsevier
Inspired by the recent advancements in understanding the binding mode of sulfonylurea-
based NLRP3 inhibitors to the NLRP3 sensor protein, we developed new NLRP3 inhibitors …

Antioxidant metabolites in primitive, wild, and cultivated citrus and their role in stress tolerance

MJ Rao, S Wu, M Duan, L Wang - Molecules, 2021 - mdpi.com
The genus Citrus contains a vast range of antioxidant metabolites, dietary metabolites, and
antioxidant polyphenols that protect plants from unfavorable environmental conditions …