The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of
modified chromatin decorated with bactericidal proteins from granules and cytoplasm …

Reactive oxygen species (ROS) are subcellular messengers in signal transductions
pathways with both beneficial and deleterious roles. ROS are generated as a by-product of …

Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant
origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy …

Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …

Heart disease is the leading cause of death worldwide. A key pathogenic factor in the
development of lethal heart failure is loss of terminally differentiated cardiomyocytes …

Diabetes mellitus is one of the major public health problems worldwide. Considerable recent
evidence suggests that the cellular reduction-oxidation (redox) imbalance leads to oxidative …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …