RecBCD enzyme and the repair of double-stranded DNA breaks
MS Dillingham, SC Kowalczykowski - Microbiology and Molecular …, 2008 - Am Soc Microbiol
SUMMARY The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the
repair of double-stranded DNA breaks by homologous recombination. It also degrades …
repair of double-stranded DNA breaks by homologous recombination. It also degrades …
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Helicases and nucleic acid translocases are motor proteins that have essential roles in
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin …
Diffusion of human replication protein A along single-stranded DNA
B Nguyen, J Sokoloski, R Galletto, EL Elson… - Journal of molecular …, 2014 - Elsevier
Replication protein A (RPA) is a eukaryotic single-stranded DNA (ssDNA) binding protein
that plays critical roles in most aspects of genome maintenance, including replication …
that plays critical roles in most aspects of genome maintenance, including replication …
Förster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulers
Advanced microscopy methods allow obtaining information on (dynamic) conformational
changes in biomolecules via measuring a single molecular distance in the structure. It is …
changes in biomolecules via measuring a single molecular distance in the structure. It is …
Spectroscopic studies of position-specific DNA 'breathing'fluctuations at replication forks and primer-template junctions
344a Monday, March 2, 2009 occurs at these ss-dsDNA junctions and the physiological
consequences of this 'breathing'is not well understood, in part because it has been difficult to …
consequences of this 'breathing'is not well understood, in part because it has been difficult to …
The processing of double-stranded DNA breaks for recombinational repair by helicase–nuclease complexes
JTP Yeeles, MS Dillingham - DNA repair, 2010 - Elsevier
Double-stranded DNA breaks are prepared for recombinational repair by nucleolytic
digestion to form single-stranded DNA overhangs that are substrates for RecA/Rad51 …
digestion to form single-stranded DNA overhangs that are substrates for RecA/Rad51 …
DNA binding to RecD: role of the 1B domain in SF1B helicase activity
K Saikrishnan, SP Griffiths, N Cook, R Court… - The EMBO …, 2008 - embopress.org
The molecular mechanism of superfamily 1Bα helicases remains unclear. We present here
the crystal structure of the RecD2 helicase from Deinococcus radiodurans at 2.2‐Å …
the crystal structure of the RecD2 helicase from Deinococcus radiodurans at 2.2‐Å …
Homologous recombination—enzymes and pathways
B Michel, D Leach - EcoSal Plus, 2012 - Am Soc Microbiol
Homologous recombination is an ubiquitous process that shapes genomes and repairs DNA
damage. The reaction is classically divided into three phases: presynaptic, synaptic, and …
damage. The reaction is classically divided into three phases: presynaptic, synaptic, and …
Mechanism for nuclease regulation in RecBCD
In bacterial cells, processing of double-stranded DNA breaks for repair by homologous
recombination is catalysed by AddAB, AdnAB or RecBCD-type helicase-nucleases. These …
recombination is catalysed by AddAB, AdnAB or RecBCD-type helicase-nucleases. These …
Insights into Chi recognition from the structure of an AddAB‐type helicase–nuclease complex
K Saikrishnan, JT Yeeles, NS Gilhooly… - The EMBO …, 2012 - embopress.org
In bacterial cells, processing of double‐stranded DNA breaks for repair by homologous
recombination is dependent upon the recombination hotspot sequence Chi and is catalysed …
recombination is dependent upon the recombination hotspot sequence Chi and is catalysed …