[HTML][HTML] Advances in research on bioactivity, toxicity, metabolism, and pharmacokinetics of usnic acid in vitro and in vivo

H Wang, M Xuan, C Huang, C Wang - Molecules, 2022 - mdpi.com
Lichens are among the most widely distributed plants on earth and have the longest growth
cycle. Usnic acid is an abundant characteristic secondary metabolite of lichens and the …

[HTML][HTML] Linking lichen metabolites to genes: emerging concepts and lessons from molecular biology and metagenomics

G Singh - Journal of Fungi, 2023 - mdpi.com
Lichen secondary metabolites have tremendous pharmaceutical and industrial potential.
Although more than 1000 metabolites have been reported from lichens, less than 10 have …

[HTML][HTML] Anti-inflammatory and analgesic potential of leaf extract of Justicia adhatoda L.(Acanthaceae) in Carrageenan and Formalin-induced models by targeting …

A Basit, T Shutian, A Khan, SM Khan… - Biomedicine & …, 2022 - Elsevier
Plants are regarded as a valuable and inexpensive source of new drug development, and a
variety of plant compounds are now being used in clinical trials to treat a variety of ailments …

[HTML][HTML] Depside and depsidone synthesis in lichenized fungi comes into focus through a genome-wide comparison of the olivetoric acid and physodic acid …

G Singh, D Armaleo, F Dal Grande, I Schmitt - Biomolecules, 2021 - mdpi.com
Primary biosynthetic enzymes involved in the synthesis of lichen polyphenolic compounds
depsides and depsidones are non-reducing polyketide synthases (NR-PKSs), and …

[HTML][HTML] Is Caperatic Acid the Only Compound Responsible for Activity of Lichen Platismatia glauca within the Nervous System?

E Studzińska-Sroka, A Majchrzak-Celińska… - Antioxidants, 2022 - mdpi.com
Lichens are a source of various biologically active compounds. However, the knowledge
about them is still scarce, and their use in medicine is limited. This study aimed to investigate …

[HTML][HTML] Identification of a lichen depside polyketide synthase gene by heterologous expression in Saccharomyces cerevisiae

JT Kealey, JP Craig, PJ Barr - Metabolic Engineering Communications, 2021 - Elsevier
Lichen-forming fungi produce a variety of secondary metabolites including bioactive
polyketides. Advances in DNA and RNA sequencing have led to a growing database of new …

[HTML][HTML] Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells

LA Roser, P Erkoc, R Ingelfinger, M Henke… - Biomedicine & …, 2022 - Elsevier
Lichen extracts containing, among other compounds, depsides such as evernic acid,
atranorin, and lecanoric acid possess anti-proliferative effects. We aimed to identify lichen …

[HTML][HTML] The pharmacological potential of novel melittin variants from the honeybee and solitary bees against inflammation and cancer

P Erkoc, BM von Reumont, T Lüddecke, M Henke… - Toxins, 2022 - mdpi.com
The venom of honeybees is composed of numerous peptides and proteins and has been
used for decades as an anti-inflammatory and anti-cancer agent in traditional medicine …

[HTML][HTML] Venomics of the milos viper (Macrovipera schweizeri) unveils patterns of venom composition and exochemistry across blunt-nosed viper venoms

L Schulte, M Damm, I Avella, L Uhrig… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Snakebite is a neglected tropical disease and a globally important driver of
death and morbidity. Vipers of the genus Macrovipera (Viperidae: Viperinae) are among the …

[HTML][HTML] Methodological aspects of green extraction of usnic acid using natural deep eutectic solvents

M Kulinowska, S Dresler, A Skalska-Kamińska… - Molecules, 2023 - mdpi.com
Usnic acid (UA) is a compound with multiple biological activities that make it useful in
various industries, eg, pharmaceutical, cosmetic, dentistry, and agricultural sectors. Lichens …