Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and
cardiovascular disease in women and therefore represents a potential target for early …

Childhood obesity is a growing and alarming problem, associated with several short-term
and long-term metabolic and cardiovascular complications. In addition, it has also been …

In lifecourse studies that encompass the adolescent period, the assessment of pubertal
status is important, but can be challenging. We aimed to identify current methods for pubertal …

Importance There has been a worldwide secular trend toward earlier onset of puberty in the
general population. However, it remains uncertain if these changes are paralleled with …

Understanding of the genetic regulation of puberty timing has come largely from studies of
rare disorders and population-based studies in women. Here, we report the largest genomic …

Background Earlier puberty is widely linked with future obesity and cardiometabolic disease.
We examined whether age at puberty onset likely influences adiposity and cardiometabolic …

Context Obesity is known to impact reproductive function in adults, but little is known about
its effects on reproductive hormones during puberty. Objective To assess sex differences in …

Background Observational studies on pubertal timing and asthma, mainly performed in
females, have provided conflicting results about a possible association of early puberty with …

Background: Early postnatal rapid 'catch-up'weight gain has been consistently associated
with subsequent higher obesity risk and earlier pubertal development. In many low-and …

Aims Obesity and early puberty have been reported to be mutually causative. We
investigated the causal relationship between adiposity and early puberty by performing …