The myriad of peptides presented at the cell surface by class I and class II major
histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-
DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of …

Summary Although CD8+ T-cell-mediated autoimmune β cell destruction occurs in type 1
diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To …

Susceptibility and protection against human autoimmune diseases, including type I
diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human …

Current knowledge about the dynamics of antigen presentation to T cells during viral
infection is very poor despite being of fundamental importance to our understanding of anti …

The HLA-DRB1 locus is strongly associated with rheumatoid arthritis (RA) susceptibility,
whereupon citrullinated self-peptides bind to HLA-DR molecules bearing the shared epitope …

Objective The association of HLA–B27 with spondyloarthropathy is one of the strongest
documented for any autoimmune disease. A common hypothesis for this association is the …

In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in
several mouse and human haplotypes has increased our understanding of the molecular …