Aging and Parkinson's disease: Different sides of the same coin?

TJ Collier, NM Kanaan, JH Kordower - Movement Disorders, 2017 - Wiley Online Library
Despite abundant epidemiological evidence in support of aging as the primary risk factor for
PD, biological correlates of a connection have been elusive. In this article, we address the …

[HTML][HTML] The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson's disease

SYY Pang, PWL Ho, HF Liu, CT Leung, L Li… - Translational …, 2019 - Springer
Background Parkinson's disease (PD) is characterized by dopaminergic neuronal loss in the
substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB). During …

Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review

B Dinda, M Dinda, G Kulsi, A Chakraborty… - European Journal of …, 2019 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related
neurodegenerative disorders, affecting several millions of aged people globally. Among …

[HTML][HTML] The gut and Parkinson's disease—a bidirectional pathway

SF Santos, HL De Oliveira, ES Yamada… - Frontiers in …, 2019 - frontiersin.org
Humans evolved a symbiotic relationship with their gut microbiome, a complex microbial
community composed of bacteria, archaea, protists, and viruses, including bacteriophages …

[HTML][HTML] Modeling Parkinson's Disease in C. elegans

JF Cooper, JM Van Raamsdonk - Journal of Parkinson's …, 2018 - content.iospress.com
Parkinson's disease (PD) is an adult onset neurodegenerative disease that is characterized
by selective degeneration of neurons primarily in the substantia nigra. At present, the …

[HTML][HTML] Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

G Brunetti, G Di Rosa, M Scuto, M Leri… - International journal of …, 2020 - mdpi.com
Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in
maintaining health, especially during ageing. Even neurodegeneration, which is part of the …

[HTML][HTML] Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models

G Di Rosa, G Brunetti, M Scuto… - International Journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative
disorder, affecting 1% of the population after the age of about 60 years old and 4% of those …

[HTML][HTML] Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans

MM Senchuk, DJ Dues, CE Schaar, BK Johnson… - PLoS …, 2018 - journals.plos.org
Mild deficits in mitochondrial function have been shown to increase lifespan in multiple
species including worms, flies and mice. Here, we study three C. elegans mitochondrial …

[HTML][HTML] Older adults and individuals with Parkinson's disease control posture along suborthogonal directions that deviate from the traditional anteroposterior and …

M Mangalam, DG Kelty-Stephen, I Seleznov… - Scientific Reports, 2024 - nature.com
A rich and complex temporal structure of variability in postural sway characterizes healthy
and adaptable postural control. However, neurodegenerative disorders such as Parkinson's …

Neuroinflammation: An overview of neurodegenerative and metabolic diseases and of biotechnological studies

AP de Araújo Boleti, TM de Oliveira Flores… - Neurochemistry …, 2020 - Elsevier
Neuroinflammation is an important factor contributing to cognitive impairment and
neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) …