[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19
and are especially important in high-risk individuals where vaccination is not an option …
and are especially important in high-risk individuals where vaccination is not an option …
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …
[HTML][HTML] Molecular basis of receptor binding and antibody neutralization of Omicron
Q Hong, W Han, J Li, S Xu, Y Wang, C Xu, Z Li, Y Wang… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant exhibits striking immune evasion and is
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …
spreading rapidly worldwide. Understanding the structural basis of the high transmissibility …
BNT162b vaccines protect rhesus macaques from SARS-CoV-2
AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - Nature, 2021 - nature.com
A safe and effective vaccine against COVID-19 is urgently needed in quantities that are
sufficient to immunize large populations. Here we report the preclinical development of two …
sufficient to immunize large populations. Here we report the preclinical development of two …
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus
H Yao, Y Song, Y Chen, N Wu, J Xu, C Sun, J Zhang… - Cell, 2020 - cell.com
SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
Structures and distributions of SARS-CoV-2 spike proteins on intact virions
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by
a lipid bilayer from which spike (S) protein trimers protrude. Heavily glycosylated S trimers …
a lipid bilayer from which spike (S) protein trimers protrude. Heavily glycosylated S trimers …
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to
develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein …
develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein …
Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …
The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens
L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …