Genomic complexity of multiple myeloma and its clinical implications
Multiple myeloma (MM) is a genetically complex disease that evolves from pre-malignant
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …
stages, such as monoclonal gammaopathy of undetermined significance and smouldering …
Cell of origin and genetic alterations in the pathogenesis of multiple myeloma
BG Barwick, VA Gupta, PM Vertino… - Frontiers in …, 2019 - frontiersin.org
B cell activation and differentiation yields plasma cells with high affinity antibodies to a given
antigen in a time-frame that allows for host protection. Although the end product is most …
antigen in a time-frame that allows for host protection. Although the end product is most …
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
M Larrayoz, MJ Garcia-Barchino, J Celay… - Nature Medicine, 2023 - nature.com
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple
myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this …
myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this …
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1
rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non …
rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non …
Diverse mutational landscapes in human lymphocytes
HE Machado, E Mitchell, NF Øbro, K Kübler, M Davies… - Nature, 2022 - nature.com
The lymphocyte genome is prone to many threats, including programmed mutation during
differentiation, antigen-driven proliferation and residency in diverse microenvironments …
differentiation, antigen-driven proliferation and residency in diverse microenvironments …
Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma
Purpose At the molecular level, myeloma is characterized by copy number abnormalities
and recurrent translocations into the immunoglobulin heavy chain locus. Novel methods …
and recurrent translocations into the immunoglobulin heavy chain locus. Novel methods …
Genomic landscape and chronological reconstruction of driver events in multiple myeloma
The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and
post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using …
post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using …
APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma
We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI
study using whole exome sequencing. Here we identify mutations induced as a …
study using whole exome sequencing. Here we identify mutations induced as a …
Multiple myeloma with high-risk cytogenetics and its treatment approach
I Hanamura - International Journal of Hematology, 2022 - Springer
Despite substantial advances in anti-myeloma treatments, early recurrence and death
remain an issue in certain subpopulations. Cytogenetic abnormalities (CAs) are the most …
remain an issue in certain subpopulations. Cytogenetic abnormalities (CAs) are the most …
Revealing the impact of structural variants in multiple myeloma
EH Rustad, VD Yellapantula, D Glodzik… - Blood cancer …, 2020 - AACR
The landscape of structural variants (SV) in multiple myeloma remains poorly understood.
Here, we performed comprehensive analysis of SVs in a large cohort of 752 patients with …
Here, we performed comprehensive analysis of SVs in a large cohort of 752 patients with …