Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

A fundamental feature of multicellular organisms is their ability to self-repair wounds through
the movement of epithelial cells into the damaged area. This collective cellular movement is …

Cell motility is required for diverse biological processes including development, homing of
immune cells, wound healing, and cancer cell invasion. Motile neutrophils exhibit a …

The nucleus has long been postulated to play a critical physical role during cell polarization
and migration, but that role has not been defined or rigorously tested. Here, we enucleated …

The extracellular matrix (ECM) is a complex, dynamic network present within all tissues and
organs that not only acts as a mechanical support and anchorage point but can also direct …

Basic human functions such as breathing and digestion require mechanical stretching of
cells and tissues. However, when it comes to laboratory experiments, the mechanical …

The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …

Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the
vasculature. They disseminate through host tissues by a process of cell-to-cell spread that …

Endothelial cells respond to changes in subendothelial stiffness by altering their migration
and mechanics, but whether those responses are due to transcriptional reprogramming …