One of the most important achievements of bacteria is its capability to adapt to the changing
conditions of the environment. The competition for nutrients with other microorganisms …

Phosphorous, in the form of phosphate, is a key element in the nutrition of all living beings.
In nature, it is present in the form of phosphate salts, organophosphates, and phosphonates …

Bacteria of the Streptomyces genus constitute an authentic biotech gold mine thanks to their
ability to produce a myriad of compounds and enzymes of great interest at various clinical …

Soil dwelling Streptomyces species are faced with large variations in carbon or nitrogen
sources, phosphate, oxygen, iron, sulfur, and other nutrients. These drastic changes in key …

Phosphate limitation is important for production of antibiotics and other secondary
metabolites in Streptomyces. Phosphate control is mediated by the two-component system …

Concern over the reports of antibiotic‐resistant bacterial infections in hospitals and in the
community has been publicized in the media, accompanied by comments on the risk that we …

Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their
genetic potential, including silent and metagenomic BGCs. Although the engineered …

Protein post-translational modification (PTM) is a reversible process, which can dynamically
regulate the metabolic state of cells through regulation of protein structure, activity …

The natural soil environment of Streptomyces is characterized by variations in the availability
of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary …

Bacteria sense and respond to the stress of phosphate limitation, anticipating Pi
deletion/starvation via the two-component PhoR–PhoP system. The role of the response …