Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Simple Summary Environmental and occupational exposure to heavy metals are risk factors
for cancers. However, the molecular mechanisms of how heavy metals induce …

Colorectal carcinoma (CRC) is the third most common cancer in terms of diagnosis and the
second in terms of mortality. Recent studies have shown that various proteins, such as …

Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and
metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks …

Simple Summary YAP and TAZ are transcriptional cofactors that integrate several upstream
signals to generate context-dependent transcriptional responses. This requires extensive …

Background Analysis of circulating free DNA (cfDNA) is a promising tool for personalized
management of colorectal cancer (CRC) patients. Untargeted cfDNA analysis using whole …

Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays
a pivotal role in organ size control and tumor suppression by inhibiting proliferation and …

Abstract Cyclin-dependent kinase (CDK) 7 is best characterized for the ability to regulate
biological processes, including the cell cycle and gene transcription. Abnormal CDK7 …

The epigenome coordinates spatial-temporal specific gene expression during development
and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval …

Basic pre-clinical research based on 2D cultures have been very valuable in colorectal
cancer (CRC) research but still have failed to improve patient prognostic outcomes. This is …