Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management

S Kadura, G Raghu - European Respiratory Review, 2021 - Eur Respiratory Soc
Rheumatoid arthritis (RA) is a systemic inflammatory disorder, with the most common extra-
articular manifestation of RA being lung involvement. While essentially any of the lung …

Interstitial lung diseases induced or exacerbated by DMARDS and biologic agents in rheumatoid arthritis: a systematic literature review

C Roubille, B Haraoui - Seminars in arthritis and rheumatism, 2014 - Elsevier
Objective To review published cases of induced or exacerbated interstitial lung disease
(ILD) in rheumatoid arthritis (RA) associated with non-biologic disease-modifying …

Comorbidities in rheumatoid arthritis

K Michaud, F Wolfe - Best practice & research Clinical rheumatology, 2007 - Elsevier
Rheumatoid arthritis (RA) is often characterized by the burden of swollen joints, pain, and
decreased physical function, but less understood are the many manifestations of additional …

Methotrexate pneumonitis: review of the literature and histopathological findings in nine patients

S Imokawa, TV Colby, KO Leslie… - European Respiratory …, 2000 - Eur Respiratory Soc
Pneumonitis is a serious and unpredictable side-effect of treatment with methotrexate (MTX)
that may become life-threatening. The clinical and histological features of nine cases of MTX …

Clinical, laboratory, radiographic, and histopathologic features of methotrexate‐associated lung injury in patients with rheumatoid arthritis. A multicenter study with …

JM Kremer, GS Alarcón, ME Weinblatt… - Arthritis & …, 1997 - Wiley Online Library
Objective. To describe the clinical, laboratory, radiologic, and histopathologic features of
methotrexate (MTX)‐induced lung injury in a combined cohort of selected patients with …

Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis: a multicenter, case-control study

GS Alarcon, JM Kremer, M Macaluso… - Annals of internal …, 1997 - acpjournals.org
Background: Toxicity limits the use of methotrexate. Objective: To identify risk factors for
methotrexate-induced lung injury in patients with rheumatoid arthritis. Design: Case-control …

Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis: a double-blind, placebo-controlled trial

SL Morgan, JE Baggott, WH Vaughn… - Annals of internal …, 1994 - acpjournals.org
Objective: To determine the effect of two different weekly doses of folic acid on the toxicity
and efficacy of low-dose methotrexate therapy for rheumatoid arthritis. Design: Randomized …

Methotrexate and interstitial lung disease: controversies and questions. A narrative review of the literature

GE Fragoulis, R Conway, E Nikiphorou - Rheumatology, 2019 - academic.oup.com
MTX, which is the anchor-drug for the treatment of RA, has been associated with lung injury
and in particular with MTX-related pneumonitis (M-pneu). Although the frequency of M-pneu …

Lung disease in rheumatoid arthritis

ZX Yunt, JJ Solomon - Rheumatic Disease Clinics, 2015 - rheumatic.theclinics.com
Rheumatoid arthritis (RA) is a progressive, systemic autoimmune disorder characterized by
articular and extra-articular manifestations. The lung is commonly a site of extra-articular …

Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid …

KH Yu, HH Chen, TT Cheng, YJ Jan, MY Weng, YJ Lin… - Medicine, 2022 - journals.lww.com
Background: Rheumatoid arthritis (RA)-related comorbidities, including cardiovascular
disease (CVD), osteoporosis (OP), and interstitial lung disease (ILD), are sub-optimally …