[HTML][HTML] Biomedical applications of engineered heparin-based materials

EN Zare, D Khorsandi, A Zarepour, H Yilmaz… - Bioactive Materials, 2024 - Elsevier
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic
backbone. Due to its fascinating chemical and physical properties, nontoxicity …

Cell therapy of peripheral arterial disease: from experimental findings to clinical trials

Z Raval, DW Losordo - Circulation research, 2013 - Am Heart Assoc
The age-adjusted prevalence of peripheral arterial disease in the US population was
estimated to approach 12% in 1985, and as the population ages, the overall population …

PPAR beta/delta and the hallmarks of cancer

N Wagner, KD Wagner - Cells, 2020 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone
receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma …

Physiological functions of peroxisome proliferator-activated receptor β

JG Neels, PA Grimaldi - Physiological reviews, 2014 - journals.physiology.org
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …

Peroxisome proliferator-activated receptor δ regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury

KJ Yin, Z Deng, M Hamblin, Y Xiang… - Journal of …, 2010 - Soc Neuroscience
Cerebral vascular endothelial cell (CEC) degeneration significantly contributes to blood–
brain barrier (BBB) breakdown and neuronal loss after cerebral ischemia. Recently …

PPARs and the cardiovascular system

M Hamblin, L Chang, Y Fan, J Zhang… - Antioxidants & redox …, 2009 - liebertpub.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

KD Wagner, N Wagner - Pharmacology & therapeutics, 2010 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors. They function as
ligand activated transcription factors. They exist in three isoforms, PPARα, PPARβ (formerly …

Modulating putative endothelial progenitor cells for the treatment of endothelial dysfunction and cardiovascular complications in diabetes

J Wils, J Favre, J Bellien - Pharmacology & therapeutics, 2017 - Elsevier
Diabetes induces a decrease in the number and function of different pro-angiogenic cell
types generically designated as putative endothelial progenitor cells (EPC), which …

PPARβ/δ: linking metabolism to regeneration

A Magadum, FB Engel - International Journal of Molecular Sciences, 2018 - mdpi.com
In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …

Current perspective of pathophysiological and interventional effects on endothelial progenitor cell biology: focus on PI3K/AKT/eNOS pathway

BR Everaert, EM Van Craenenbroeck… - International journal of …, 2010 - Elsevier
For more than a decade, endothelial progenitor cells (EPCs) have been implicated in
cardiovascular homeostasis. EPCs are believed to reside within the bone marrow in close …