A comprehensive description of how neurons and entire brain regions are interconnected is
fundamental for a mechanistic understanding of brain function and dysfunction …

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the
brain, with a range of applications in both clinical and basic neuroscience. Despite …

Characterizing and understanding the limitations of diffusion MRI fiber tractography is a
prerequisite for methodological advances and innovations which will allow these techniques …

Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image
both the macroscopic trajectories and the microstructural properties of axon bundles in vivo …

Diffusion MRI (dMRI) fiber tractography has become a pillar of the neuroimaging community
due to its ability to noninvasively map the structural connectivity of the brain. Despite …

MR Tractography, which is based on MRI measures of water diffusivity, is currently the only
method available for noninvasive reconstruction of fiber pathways in the brain. However, it …

Multiple sclerosis leads to diffuse damage of the central nervous system, affecting also the
normal-appearing white matter. Demyelination and axonal degeneration reduce regional …

Diffusion-weighted magnetic resonance imaging (DW-MRI) tractography is a non-invasive
tool to probe neural connections and the structure of the white matter. It has been applied …

Axonal conduction velocity, which ensures efficient function of the brain network, is related to
axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion …