Demonstrations that grip strength has predictive power in relation to a range of health
conditions—even when these are assessed decades later—has motivated claims that hand …

Nervous system deterioration is a primary driver of age‐related motor impairment. The motor
neurones, which act as the interface between the central nervous system and the muscles …

Reasons for the progressive age-related loss of skeletal muscle mass and function, namely
sarcopenia, are complex. Few studies describe sarcopenia in mice, although this species is …

The deterioration of skeletal muscle with advancing age has long been anecdotally
recognized and has been of scientific interest for more than 150 years. Over the past several …

Muscle atrophy in many conditions share a common mechanism in the upregulation of the
muscle-specific ubiquitin E3-ligases atrophy gene-1/muscle atrophy F-box (Atrogin …

Motor disturbances and wasting of skeletal muscles (sarcopenia) causes significant
impairment of daily life activities and is a major underlying cause for hospitalization in …

This paper summarizes the various effects of neurotrophins in skeletal muscle and how
these proteins act as potential regulators of the maintenance, function, and regeneration of …

Several disturbances occurring during aging of humans and rodents alike stem from
changes in sensory and motor functions. Using a battery of behavioral tests we have studied …

Using a range of tests we have studied alterations in behavior with advancing age in female
C57BL/6 (of Jackson origin), the golden standard on which most genetically engineered …

The age-related loss of skeletal muscle mass and function that is associated with sarcopenia
can result in ultimate consequences such as decreased quality of life. The causes of …