The presence of a diabetic cardiomyopathy, independent of hypertension and coronary
artery disease, is still controversial. This systematic review seeks to evaluate the evidence …

Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease.
The endothelium controls the tone of the underlying vascular smooth muscle through the …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

Diabetes mellitus is associated with moderate cognitive deficits and neurophysiological and
structural changes in the brain, a condition that may be referred to as diabetic …

Nitric oxide (NO) is a potent vasodilator that was initially described as the mediator of
endothelium-dependent relaxation (endothelium-derived relaxing factor, EDRF). It is now …

Diabetes mellitus is a common metabolic disorder associated with chronic complications
such as nephropathy, angiopathy, retinopathy and peripheral neuropathy. Diabetes is not …

Several studies have shown impairement of endothelium-dependent relaxations as well as
increased release of vasoconstrictor prostanoids in arteries from diabetic animals and …

The impact of vascular risk factors on cognitive function has garnered much interest in recent
years. The appropriate distribution of oxygen, glucose, and other nutrients by the cerebral …

Protein kinase C (PKC) is activated in rat renal glomerulus within a week of induction of
experimental diabetes. Studies in isolated glomeruli and in cultured endothelial and …

Nitric oxide (NO) is a highly reactive free radical with a multitude of organ specific regulatory
functions. Since 1985. NO has been the subject of numerous research efforts and as a …