The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …

The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …

One of the hallmarks of cancers is the silencing of tumour suppressor genes and pathways.
The Hippo tumour suppressor pathway is inactivated in many types of cancers, leading to …

The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

Rationale: In Drosophila, the Hippo signaling pathway negatively regulates organ size by
suppressing cell proliferation and survival through the inhibition of Yorkie, a transcriptional …

The Hippo pathway plays a crucial role in regulating tissue homeostasis and organ size, and
its deregulation is frequently observed in human cancer. Yap is the major effector of and is …

The Hippo pathway was originally identified as the signaling that controls organ size in
Drosophila, with the core architecture conserved in mammals. In the mammalian Hippo …