Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring
M Denizli, ML Capitano, KL Kua - Frontiers in cellular and infection …, 2022 - frontiersin.org
The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …
The early life education of the immune system: Moms, microbes and (missed) opportunities
N Jain - Gut Microbes, 2020 - Taylor & Francis
The early life immune system is characterized by unique developmental milestones.
Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a …
Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a …
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
TK Soderborg, SE Clark, CE Mulligan… - Nature …, 2018 - nature.com
Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …
The initiation of metabolic inflammation in childhood obesity
An understanding of the events that initiate metabolic inflammation (metainflammation) can
support the identification of targets for preventing metabolic disease and its negative effects …
support the identification of targets for preventing metabolic disease and its negative effects …
Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring
MJ Nash, E Dobrinskikh, TK Soderborg, RC Janssen… - Cell reports, 2023 - cell.com
Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal
offspring. This constitutes a major public health concern due to increasing prevalence of …
offspring. This constitutes a major public health concern due to increasing prevalence of …
Developmental programming of obesity and diabetes in mouse, monkey, and man in 2018: where are we headed?
JE Friedman - Diabetes, 2018 - Am Diabetes Assoc
Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds
of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes …
of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes …
Vascular stiffness in insulin resistance and obesity
G Jia, AR Aroor, VG DeMarco… - Frontiers in …, 2015 - frontiersin.org
Obesity, insulin resistance, and type 2 diabetes are associated with a substantially
increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of …
increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of …
Early microbes modify immune system development and metabolic homeostasis—the “restaurant” hypothesis revisited
MJ Nash, DN Frank, JE Friedman - Frontiers in endocrinology, 2017 - frontiersin.org
The developing infant gut microbiome affects metabolism, maturation of the gastrointestinal
tract, immune system function, and brain development. Initial seeding of the neonatal …
tract, immune system function, and brain development. Initial seeding of the neonatal …
Pediatric non-alcoholic fatty liver disease: nutritional origins and potential molecular mechanisms
Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide
and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric …
and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric …
[PDF][PDF] Plasticity across generations
R Bonduriansky - Phenotypic plasticity & evolution, 2021 - library.oapen.org
Previous chapters have outlined the classic concept of plasticity, its mechanistic basis, and
its adaptive importance. Plasticity is the ability of an individual organism or genotype to …
its adaptive importance. Plasticity is the ability of an individual organism or genotype to …