The prevalence of obesity is increasingly common in the United States, with~ 25% of women
of reproductive age being overweight or obese. Metaflammation, a chronic low grade …

The early life immune system is characterized by unique developmental milestones.
Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a …

Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic
fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early …

An understanding of the events that initiate metabolic inflammation (metainflammation) can
support the identification of targets for preventing metabolic disease and its negative effects …

Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal
offspring. This constitutes a major public health concern due to increasing prevalence of …

Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds
of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes …

Obesity, insulin resistance, and type 2 diabetes are associated with a substantially
increased prevalence of vascular fibrosis and stiffness, with attendant increased risk of …

The developing infant gut microbiome affects metabolism, maturation of the gastrointestinal
tract, immune system function, and brain development. Initial seeding of the neonatal …

Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide
and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric …

Previous chapters have outlined the classic concept of plasticity, its mechanistic basis, and
its adaptive importance. Plasticity is the ability of an individual organism or genotype to …