Understanding mechanisms that underly the transition from acute to chronic pain and
identifying potential targets for preventing or minimizing this progression have specific …

Given that adolescence is a significant period of brain plasticity and development, early life
factors have the potential to alter long term outcomes. For instance, adversities such as …

Adverse childhood experiences (ACEs) affect over half of the adults in the United States and
are known to contribute to the development of a wide variety of negative health and …

Child maltreatment disrupts trajectories of brain development, but the underlying pathways
are unclear. Stressful stimuli in early life interfere with maturation of local inhibitory circuitry …

Persistent postsurgical pain affects 20% of youth undergoing a surgical procedure, with
females exhibiting increased prevalence of chronic pain compared with males. This study …

Adolescent chronic pain is a growing public health epidemic. Our understanding of its
etiology is limited; however, several factors can increase susceptibility, often developing in …

Obesity is one of the biggest and most costly health challenges the modern world
encounters. Substantial evidence suggests that the risk of metabolic syndrome or obesity …

The perinatal period encompasses a critical window for neurodevelopment that renders the
brain highly responsive to experience. Trauma, such as intimate partner violence (IPV) and …

Children and adolescents with chronic pain are at an increased risk of suicidality. This
narrative review article aims to inform clinical practice in the assessment and management …

Exposure to severely stressful events during childhood is associated with poor health
outcomes in later life, including chronic pain and substance use disorder. However, the …