Oestradiol as a neuromodulator of learning and memory

LR Taxier, KS Gross, KM Frick - Nature Reviews Neuroscience, 2020 - nature.com
Although hormones such as glucocorticoids have been broadly accepted in recent decades
as general neuromodulators of memory processes, sex steroid hormones such as the potent …

[HTML][HTML] Estradiol and cognitive function: past, present and future

VN Luine - Hormones and behavior, 2014 - Elsevier
A historical perspective on estradiol's enhancement of cognitive function is presented, and
research, primarily in animals, but also in humans, is reviewed. Data regarding the …

Sex differences in antidepressant efficacy

TA LeGates, MD Kvarta, SM Thompson - Neuropsychopharmacology, 2019 - nature.com
Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …

Sex differences in the brain: Implications for behavioral and biomedical research

E Choleris, LAM Galea, F Sohrabji, KM Frick - … & Biobehavioral Reviews, 2018 - Elsevier
Biological differences between males and females are found at multiple levels. However,
females have too often been under-represented in behavioral neuroscience research, which …

Structural plasticity of the hippocampus in response to estrogens in female rodents

PAS Sheppard, E Choleris, LAM Galea - Molecular brain, 2019 - Springer
It is well established that estrogens affect neuroplasticity in a number of brain regions. In
particular, estrogens modulate and mediate spine and synapse formation as well as …

Epigenetic regulation of gene expression in physiological and pathological brain processes

J Gräff, D Kim, MM Dobbin, LH Tsai - Physiological reviews, 2011 - journals.physiology.org
Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

KM Frick, J Kim, JJ Tuscher, AM Fortress - Learning & Memory, 2015 - learnmem.cshlp.org
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen
17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and …

Plasma membrane estrogen receptors

ER Levin - Trends in Endocrinology & Metabolism, 2009 - cell.com
It is now firmly established that estrogen and all sex steroid receptors exist in discrete
cellular pools outside the nucleus. Estrogen receptors (ER) have been localized to the …

Sex differences in hippocampal function

WA Koss, KM Frick - Journal of neuroscience research, 2017 - Wiley Online Library
Sex differences in the function of the hippocampus have been observed in numerous
mammalian species. However, the magnitude, extent, and specificity of these differences are …

Why estrogens matter for behavior and brain health

LAM Galea, KM Frick, E Hampson, F Sohrabji… - Neuroscience & …, 2017 - Elsevier
Abstract The National Institutes of Health (NIH) has required the inclusion of women in
clinical studies since 1993, which has enhanced our understanding of how biological sex …