The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

The glucoregulatory hormones insulin and glucagon are released from the β-and α-cells of
the pancreatic islets. In both cell types, secretion is secondary to firing of action potentials …

Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis and liver
glycogen breakdown. The mechanism regulating glucagon release is debated, and …

Abstract Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …

Glucagon is released from α-cells present in intact pancreatic islets at glucose
concentrations below 4 mm, whereas higher glucose levels inhibit its secretion. The …

Glucose homeostasis is regulated primarily by the opposing actions of insulin and glucagon,
hormones that are secreted by pancreatic islets from β-cells and α-cells, respectively. Insulin …

Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis,
and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate …