Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids

PS Auti, G George, AT Paul - RSC advances, 2020 - pubs.rsc.org
Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives

M Asif - International journal of medicinal chemistry, 2014 - Wiley Online Library
The heterocyclic fused rings quinazoline and quinazolinone have drawn a huge
consideration owing to their expanded applications in the field of pharmaceutical chemistry …

The aza-Wittig reaction: an efficient tool for the construction of carbon–nitrogen double bonds

F Palacios, C Alonso, D Aparicio, G Rubiales… - Tetrahedron, 2007 - Elsevier
Recent advances in the aza-Wittig reaction of phosphazene derivatives with several
carbonyl compounds are reviewed. Phosphazenes afford inter-and intramolecular aza-Wittig …

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

S Ananthan, ER Faaleolea, RC Goldman, JV Hobrath… - Tuberculosis, 2009 - Elsevier
There is an urgent need for the discovery and development of new antitubercular agents that
target new biochemical pathways and treat drug resistant forms of the disease. One …

Synergistic catalysis on Fe–N x sites and Fe nanoparticles for efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes

Z Ma, T Song, Y Yuan, Y Yang - Chemical science, 2019 - pubs.rsc.org
In this paper, we developed a reusable heterogeneous non-precious iron nanocomposite
comprising metallic Fe–Fe3C nanoparticles and Fe–Nx sites on N-doped porous carbon …

Chemical insights into the synthetic chemistry of quinazolines: Recent advances

M Faisal, A Saeed - Frontiers in chemistry, 2021 - frontiersin.org
In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines,
possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV …

Nanocatalyzed synthetic approach for quinazoline and quinazolinone derivatives: A review (2015–present)

P Kumar, V Tomar, RK Joshi… - Synthetic …, 2022 - Taylor & Francis
Quinazolines and their derivative are among the most significant heterocyclic compounds
due to their several chemical reactivities and vital range of biological activity. Although a …

Electrochemical Skeletal Indole Editing via Nitrogen Atom Insertion by Sustainable Oxygen Reduction Reaction

BS Zhang, SL Homölle, T Bauch… - Angewandte Chemie …, 2024 - Wiley Online Library
Skeletal molecular editing gained considerable recent momentum and emerged as a
uniquely powerful tool for late‐stage diversifications. Thus far, superstoichiometric amounts …

Antituberculosis activity of the molecular libraries screening center network library

JA Maddry, S Ananthan, RC Goldman, JV Hobrath… - Tuberculosis, 2009 - Elsevier
There is an urgent need for the discovery and development of new antitubercular agents that
target novel biochemical pathways and treat drug-resistant forms of the disease. One …

Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

FE Held, AA Guryev, T Fröhlich, F Hampel… - Nature …, 2017 - nature.com
Most of the known approved drugs comprise functionalized heterocyclic compounds as
subunits. Among them, non-fluorescent quinazolines with four different substitution patterns …