Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y
receptors. P2X receptors are membrane ion channels preferably permeable to sodium …

Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …

Despite the great progress recently made in resolving their structures, investigation of the
structural biology of membrane proteins still presents major challenges. Even with new …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7
receptor subtype plays a crucial role in the immune and nervous systems. Altered …

Abstract ATP-gated P2X receptors are trimeric ion channels selective to cations. Recent
progress in the molecular biophysics of these channels enables a better understanding of …

P2X receptors are a family of trimeric ion channels that are gated by extracellular adenosine
5′-triphosphate (ATP). These receptors have long been a subject of intense research …

The mammalian P2X7 receptors (P2X7Rs), a member of the ionotropic P2X receptor family
with distinctive functional properties, play an important part in mediating extracellular ATP …

Allosteric modulation provides exciting opportunities for drug discovery of enzymes, ion
channels, and G protein-coupled receptors. As cation channels gated by extracellular ATP …

Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …